Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis

Christopher Hanck; Siegbert Rossol; Ulrich Böcker; Mehmet Tokus; Manfred V. Singer

doi:10.1093/alcalc/33.6.606

Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis

Christopher Hanck, Siegbert Rossol, Ulrich Böcker, Mehmet Tokus, Manfred V. Singer

Klinik für Innere Medizin - Gastroenterologie, Diabetologie und Hepatologie

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82 Zitate (Scopus)

Abstract

Cytokines and plasma endotoxin were measured in a consecutive series of patients with alcoholic cirrhosis (AC). Endotoxaemia was found to be strongly correlated to increased plasma levels of functionally active tumour necrosis factor (TNF) receptors -p55 and -p75, TNF-α, and the Child-Pugh stage of the disease. Our data support the hypothesis of the pathogenic role of lipopolysaccharide in hepatocellular damage of patients with AC.

Originalsprache	English
Seiten (von - bis)	606-608
Seitenumfang	3
Fachzeitschrift	Alcohol and Alcoholism
Jahrgang	33
Ausgabenummer	6
DOIs	https://doi.org/10.1093/alcalc/33.6.606
Publikationsstatus	Published - 1998

ASJC Scopus subject areas

Medizin (sonstige)
Toxikologie
Psychiatrie und psychische Gesundheit

UN SDGs

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AU - Singer, Manfred V.

PY - 1998

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AB - Cytokines and plasma endotoxin were measured in a consecutive series of patients with alcoholic cirrhosis (AC). Endotoxaemia was found to be strongly correlated to increased plasma levels of functionally active tumour necrosis factor (TNF) receptors -p55 and -p75, TNF-α, and the Child-Pugh stage of the disease. Our data support the hypothesis of the pathogenic role of lipopolysaccharide in hepatocellular damage of patients with AC.

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Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis

Abstract

ASJC Scopus subject areas

UN SDGs

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