Klinik für Anästhesie, operative Intensivmedizin und Schmerztherapie

2025

Patient perspectives on stress after ICU and a short primary care based psychological intervention – results from a qualitative sub‑study of the PICTURE trial

for the PICTURE study group, Dec 2025, In: BMC Primary Care. 26, 1, 12.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Treatment effect of intravenous high-dose selenium in sepsis phenotypes: a retrospective analysis of a large multicenter randomized controlled trial

the SepNet Critical Care Trials Group, Dec 2025, In: Journal of Intensive Care. 13, 1, 21.

Research output: Contribution to journal › Article › peer-review

2024

Patientin mit Symptomen einer posttraumatischen Belastung nach Intensivmedizin – ein Fallbericht der PICTURE-Studie

Translated title of the contribution: Patient with symptoms of post-traumatic stress disorder after intensive care—a case report from the PICTURE studyPICTURE-Studiengruppe, Sept 2024, In: Zeitschrift fur Allgemeinmedizin. 100, 5, p. 268-271 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Barriers and opportunities for implementation of a brief psychological intervention for post-ICU mental distress in the primary care setting – results from a qualitative sub-study of the PICTURE trial

for the PICTURE-study team, Dec 2023, In: BMC Primary Care. 24, 1, 113.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

2022

Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial

the MEDUSA study group, Dec 2022, In: Critical Care. 26, 1, 51.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis

MEDUSA study group, Dec 2022, In: Scientific Reports. 12, 1, 3925.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

2021

Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature

the MEDUSA study group, Dec 2021, In: Critical Care. 25, 1, 368.

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Präoperative Flüssigkeitskarenz: Etablierung eines liberalen Flüssigkeitsregimes mittels Nüchternheitskarten

Translated title of the contribution: Preoperative fluid fasting: Establishment of a liberal fluid regimen using fasting cardsRüggeberg, A., Dubois, P., Böcker, U. & Gerlach, H., Jun 2021, In: Anaesthesist. 70, 6, p. 469-475 7 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Sterblichkeit bei Sepsis und septischem Schock in Deutschland. Ergebnisse eines systematischen Reviews mit Metaanalyse

Translated title of the contribution: Mortality in sepsis and septic shock in Germany. Results of a systematic review and meta-analysisBauer, M., Groesdonk, H. V., Preissing, F., Dickmann, P., Vogelmann, T. & Gerlach, H., Aug 2021, In: Anaesthesist. 70, 8, p. 673-680 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts

the SOAP and ICON Investigators, Dec 2021, In: Critical Care. 25, 1, 87.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock

König, R., Kolte, A., Ahlers, O., Oswald, M., Krauss, V., Roell, D., Sommerfeld, O., Dimopoulos, G., Tsangaris, I., Antoniadou, E., Jaishankar, N., Bogatsch, H., Löffler, M., Rödel, M., Garcia-Moreno, M., Tuchscherr, L., Sprung, C. L., Singer, M., Brunkhorst, F. & Oppert, M. & 7 others, Gerlach, H., Claus, R. A., Coldewey, S. M., Briegel, J., Giamarellos-Bourboulis, E. J., Keh, D. & Bauer, M., 9 Mar 2021, In: Frontiers in immunology. 12, 607217.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

2020

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019-results from a systematic review and meta-analysis

Bauer, M., Gerlach, H., Vogelmann, T., Preissing, F., Stiefel, J. & Adam, D., 19 May 2020, In: Critical Care. 24, 1, 239.

Research output: Contribution to journal › Article › peer-review

Open Access

494 Citations (Scopus)

Positionspapier mit konkreten Handlungsempfehlungen* der DGAI und des BDA: Ökologische Nachhaltigkeit in der Anästhesiologie und Intensivmedizin

Translated title of the contribution: Ecological sustainability in anaesthesiology and intensive care medicine. A DGAI and BDA position paper with specific recommendationsKommission „Nachhaltigkeit in der Anästhesiologie, Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin e.V. (DGAI) & Berufsverbandes Deutscher Anästhesisten e.V. (BDA), Jul 2020, In: Anasthesiologie und Intensivmedizin. 61, 7-8, p. 329-339 11 p.

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

S3-leitlinie: Sepsis 2018. Prävention, diagnose, therapie und nachsorge - Zusammenfassung starker empfehlungen

Translated title of the contribution: S3 guideline: Sepsis 2018. Prevention, diagnosis, prevention, aftercare - Summary of strong recommendationsBrunkhorst, F. M., Weigand, M. A., Pletz, M., Gastmeier, P., Lemmen, S. W., Meier-Hellmann, A., Ragaller, M., Weyland, A., Marx, G., Bucher, M., Gerlach, H., Salzberger, B., Grabein, B., Welte, T., Werdan, K., Kluge, S., Bone, H. G., Putensen, C., Rossaint, R. & Quintel, M. & 14 others, Spies, C., Weiß, B., John, S., Oppert, M., Jörres, A., Brenner, T., Elke, G., Gründling, M., Mayer, K., Weimann, A., Felbinger, T. W., Axer, H., Heller, T. & Gagelmann, N., May 2020, In: Anasthesiologie und Intensivmedizin. 61, 5, p. 178-188 11 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge: Zusammenfassung starker Empfehlungen

Translated title of the contribution: S3 guideline sepsis—prevention, diagnosis, treatment, and aftercare: Summary of the strong recommendationsDeutsche Sepsis Gesellschaft e. V., 1 Apr 2020, In: Medizinische Klinik - Intensivmedizin und Notfallmedizin. 115, 3, p. 178-188 11 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2019

Current clinical use of intravenous fosfomycin in ICU patients in two European countries

Putensen, C., Ellger, B., Sakka, S. G., Weyland, A., Schmidt, K., Zoller, M., Weiler, N., Kindgen-Milles, D., Jaschinski, U., Weile, J., Lindau, S., Kieninger, M., Faltlhauser, A., Jung, N., Teschendorf, P., Adamzik, M., Gründling, M., Wahlers, T., Gerlach, H. & Litty, F. A., 1 Oct 2019, In: Infection. 47, 5, p. 827-836 10 p.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

2018

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

on behalf of the ICON and SOAP investigators & SOAP investigators, 1 Mar 2018, In: Intensive care medicine. 44, 3, p. 337-344 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Citations (Scopus)

Effect of a combined brief narrative exposure therapy with case management versus treatment as usual in primary care for patients with traumatic stress sequelae following intensive care medicine: study protocol for a multicenter randomized controlled trial (PICTURE)

PICTURE Study Group, 10 Sept 2018, In: Trials. 19, 1, 1 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Epidemiologie, Diagnostik und Therapie erwachsener Patienten mit nosokomialer Pneumonie - Update 2017∗: S3-Leitlinie der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin e.V., der Deutschen Gesellschaft für Infektiologie e.V., der Deutschen Gesellschaft für Hygiene und Mikrobiologie e.V., der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V., der Paul-Ehrlich Gesellschaft für Chemotherapie e.V, der Deutschen Röntgengesellschaft und der Gesellschaft für Virologie

Translated title of the contribution: Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia - Update 2017: S3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy, the German Radiological Society and the Society for VirologyDalhoff, K., Abele-Horn, M., Andreas, S., Deja, M., Ewig, S., Gastmeier, P., Gatermann, S., Gerlach, H., Grabein, B., Heuβel, C. P., Höffken, G., Kolditz, M., Kramme, E., Kühl, H., Lange, C., Mayer, K., Nachtigall, I., Panning, M., Pletz, M. & Rath, P. M. & 8 others, Rohde, G., Rosseau, S., Schaaf, B., Schreiter, D., Schütte, H., Seifert, H., Spies, C. & Welte, T., 1 Jan 2018, In: Pneumologie. 72, 1, p. 15-63 49 p.

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

2017

Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial

for the MEDUSA study group, 1 Nov 2017, In: Intensive care medicine. 43, 11, p. 1602-1612 11 p.

Research output: Contribution to journal › Article › peer-review

147 Citations (Scopus)

From the infection to the organ failure - Diagnosis with "clinical view"?

Gerlach, H., 2017, In: Journal fur Anasthesie und Intensivbehandlung. 2017-January, 2, p. 17-20 4 p.

Research output: Contribution to journal › Article › peer-review

Pro-con debate: The new "sepsis-3" definition is the wrong approach! Con

Gerlach, H., 2017, In: Journal fur Anasthesie und Intensivbehandlung. 2017-January, 2, p. 20-25 6 p.

Research output: Contribution to journal › Article › peer-review

Sepsis 2017: A new definition leads to new concepts

Weis, S., Dickmann, P., Pletz, M. W., Coldewey, S. M., Gerlach, H. & Bauer, M., 24 Jul 2017, In: Deutsches Arzteblatt International. 114, 29-30, p. 801-810 10 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., Rochwerg, B., Rubenfeld, G. D., Angus, D. C., Annane, D., Beale, R. J., Bellinghan, G. J., Bernard, G. R., Chiche, J. D., Coopersmith, C. & De Backer, D. P. & 39 others, French, C. J., Fujishima, S., Gerlach, H., Hidalgo, J. L., Hollenberg, S. M., Jones, A. E., Karnad, D. R., Kleinpell, R. M., Koh, Y., Lisboa, T. C., Machado, F. R., Marini, J. J., Marshall, J. C., Mazuski, J. E., McIntyre, L. A., McLean, A. S., Mehta, S., Moreno, R. P., Myburgh, J., Navalesi, P., Nishida, O., Osborn, T. M., Perner, A., Plunkett, C. M., Ranieri, M., Schorr, C. A., Seckel, M. A., Seymour, C. W., Shieh, L., Shukri, K. A., Simpson, S. Q., Singer, M., Thompson, B. T., Townsend, S. R., Van der Poll, T., Vincent, J. L., Wiersinga, W. J., Zimmerman, J. L. & Dellinger, R. P., 1 Mar 2017, In: Intensive care medicine. 43, 3, p. 304-377 74 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5050 Citations (Scopus)

2016

Definition and diagnosis of sepsis: "Good-bye, SIRS" - Review, current development and perspective

Gerlach, H., 2016, In: Journal fur Anasthesie und Intensivbehandlung. 2016-January, 2, p. 44-48 5 p.

Research output: Contribution to journal › Article › peer-review

Effect of hydrocortisone on development of shock among patients with severe sepsis the HYPRESS randomized clinical trial

Keh, D., Trips, E., Marx, G., Wirtz, S. P., Abduljawwad, E., Bercker, S., Bogatsch, H., Briegel, J., Engel, C., Gerlach, H., Goldmann, A., Kuhn, S. O., Hüter, L., Meier-Hellmann, A., Nierhaus, A., Kluge, S., Lehmke, J., Loeffler, M., Oppert, M. & Resener, K. & 7 others, Schädler, D., Schuerholz, T., Simon, P., Weiler, N., Weyland, A., Reinhart, K. & Brunkhorst, F. M., 1 Nov 2016, In: JAMA - Journal of the American Medical Association. 316, 17, p. 1775-1785 11 p.

Research output: Contribution to journal › Article › peer-review

209 Citations (Scopus)

Effect of sodium selenite administration and procalcitonin-guided therapy on mortality in patients with severe sepsis or septic shock:A randomized clinical trial

Bloos, F., Trips, E., Nierhaus, A., Briegel, J., Heyland, D. K., Jaschinski, U., Moerer, O., Weyland, A., Marx, G., Grundling, M., Kluge, S., Kaufmann, I., Ott, K., Quintel, M., Jelschen, F., Meybohm, P., Rademacher, S., Meier-Hellmann, A., Utzolino, S. & Kaisers, U. X. & 11 others, Putensen, C., Elke, G., Ragaller, M., Gerlach, H., Ludewig, K., Kiehntopf, M., Bogatsch, H., Engel, C., Brunkhorst, F. M., Loeffler, M. & Reinhart, K., 1 Sept 2016, In: JAMA Internal Medicine. 176, 9, p. 1266-1276 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

218 Citations (Scopus)

Migrant crisis in Europe: implications for intensive care specialists

Guidet, B., Gerlach, H. & Rhodes, A., 1 Feb 2016, In: Intensive care medicine. 42, 2, p. 249-251 3 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Pathophysiology of sepsis: "Task force" neutrophils - Odyssey or perfect control?

Gerlach, H., 2016, In: Journal fur Anasthesie und Intensivbehandlung. 2016-January, 2, p. 48-55 8 p.

Research output: Contribution to journal › Article › peer-review

2015

From infection to microcirculatory disturbance - Pathophysiology

Gerlach, H., 2015, In: Journal fur Anasthesie und Intensivbehandlung. 2, p. 55-59 5 p.

Research output: Contribution to journal › Article › peer-review

2014

Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: A prospective observational multi-center study

Bloos, F., Thomas-Rüddel, D., Rüddel, H., Engel, C., Schwarzkopf, D., Marshall, J. C., Harbarth, S., Simon, P., Riessen, R., Keh, D., Dey, K., Weiß, M., Toussaint, S., Schädler, D., Weyland, A., Ragaller, M., Schwarzkopf, K., Eiche, J., Kuhnle, G. & Hoyer, H. & 51 others, Hartog, C., Kaisers, U., Reinhart, K., Marx, G., Schürholz, T., Blacher, M., Kretzschmar, M., Schlegel-Höfner, H., Fischer, P., Schreiber, T., Steuckart, R., Bubser, H., Gerlach, H., Brederlau, J., Spies, C., Lubasch, A., Franke, O., Bach, F., Bachmann-Holdau, U., Lange, M., Volkert, D., Meier-Hellmann, A., Clausen, T., Niedenthal, A., Sternkopf, M., Schulz, H., Rauch, S., Gründling, M., Knöck, N., Scheiber, G., Weiler, N., Berendes, E., Nicolas, S., Anetseder, M., Textor, Z., Kaisers, U., Braun, G., Becker, K., Laubinger, R., Klein, U., Knebel, F., Sinz, R., Fischer, A., Hornberger, K., Rosenhagen, K., Seibel, A., Schummer, W., Heininger, A., Lascho, C., Schmidt, F. & Wöbker, G., 3 Mar 2014, In: Critical Care. 18, 2, R42.

Research output: Contribution to journal › Article › peer-review

184 Citations (Scopus)

Sepsis survivors monitoring and coordination in outpatient health care (SMOOTH): Study protocol for a randomized controlled trial

Schmidt, K., Thiel, P., Mueller, F., Schmuecker, K., Worrack, S., Mehlhorn, J., Engel, C., Brenk-Franz, K., Kausche, S., Jakobi, U., Bindara-Klippel, A., Schneider, N., Freytag, A., Davydow, D., Wensing, M., Brunkhorst, F. M., Gensichen, J., Kerth, S., Kuhnsch, H. & Reinhart, K. & 44 others, Geist, A., Schreiber, T., Berhold, C., Corea, M., Freitag, A., Gerlach, H., Kuehnemund, R., Lehmke, J., Lehmkuhl, P., Reil L, L., Tiedemann, G., Toissaint, S., Veit, S., Goldmann, A., Ch, H., Oppert, M., Keh, D., Rademacher, S., Spiess, C., Toepfer, L., Klefisch, F., Berlin, P. H., Rohr, U., Kern, H., Sablotzki, A., Oehmichen F, F., Pohl M, M., Meier-Hellmann A, A., Erfurt, H. C., Hamzei, F., Bak, P., Hartmann, M., Hartog, C., Strauss, B., Ehlert, U., Gauder, H., Aid, G. S., Graf, J., Stuttgart, C., Koenig, H. H., von Korff, M., Ollenschlëger, G., Berlin, A. M. & Schelling, G., 11 Jul 2014, In: Trials. 15, 1, 283.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

2013

Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: A prospective randomized multicentre study

Scheeren, T. W. L., Wiesenack, C., Gerlach, H. & Marx, G., Jun 2013, In: Journal of Clinical Monitoring and Computing. 27, 3, p. 225-233 9 p.

Research output: Contribution to journal › Article › peer-review

129 Citations (Scopus)

"lost in translation"? Zu Wirksamkeit und Wirkung von Drotrecogin α (rhAPC)

Translated title of the contribution: Lost in translation?: On the effectiveness and efficacy of drotrecogin alfa (recombinant human activated protein C)Gerlach, H., Feb 2013, In: Medizinische Klinik. 108, 1, p. 69-70 2 p.

Research output: Contribution to journal › Article › peer-review

Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012

The Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup, Feb 2013, In: Intensive care medicine. 39, 2, p. 165-228 64 p.

Research output: Contribution to journal › Article › peer-review

3660 Citations (Scopus)

Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012

The Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup, 2013, In: Critical Care Medicine. 41, 2, p. 580-637 58 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4920 Citations (Scopus)

2012

Checklisten-medizin - Mehr sicherheit?

Translated title of the contribution: Checklists-medicine - More safety?Gerlach, H., 2012, In: Journal fur Anasthesie und Intensivbehandlung. 19, 1, p. 52-54 3 p.

Research output: Contribution to journal › Article › peer-review

Die SSC-sepsis-leitlinien: Adjunktive therapie

Translated title of the contribution: The SSC sepsis guidelines: Adjunctive therapyGerlach, H., 2012, In: Journal fur Anasthesie und Intensivbehandlung. 19, 1, p. 58-60 3 p.

Research output: Contribution to journal › Article › peer-review

Evaluating the use of recombinant human activated protein C in adult severe sepsis: Results of the Surviving Sepsis Campaign

Casserly, B., Gerlach, H., Phillips, G. S., Marshall, J. C., Lemeshow, S. & Levy, M. M., May 2012, In: Critical Care Medicine. 40, 5, p. 1417-1426 10 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Low-dose steroids in adult septic shock: Results of the Surviving Sepsis Campaign

Casserly, B., Gerlach, H., Phillips, G. S., Lemeshow, S., Marshall, J. C., Osborn, T. M. & Levy, M. M., Dec 2012, In: Intensive care medicine. 38, 12, p. 1946-1954 9 p.

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Patterns and early evolution of organ failure in the intensive care unit and their relation to outcome

Sakr, Y., Lobo, S. M., Moreno, R. P., Gerlach, H., Ranieri, V. M., Michalopoulos, A. & Vincent, J. L., 16 Nov 2012, In: Critical Care. 16, 6, R222.

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Von der infektion zur mikrozirkulationsstörung: Pathophysiologie

Translated title of the contribution: From infection to microcirculatory disturbance: PathophysiologyGerlach, H., 2012, In: Journal fur Anasthesie und Intensivbehandlung. 19, 1, p. 54-58 5 p.

Research output: Contribution to journal › Article › peer-review

2011

Implementierung neuer Standards in der Anästhesie: Beispiel der Ad-hoc-Einführung von Desfluran an 10 deutschen Krankenhäusern

Translated title of the contribution: Implementation of new standards in anaesthesia: Exemplified by the ad hoc introduction of desflurane in 10 German hospitalsEberhart, L. H. J., Gerlach, H., Knaber, R., Koch, T., Morin, A. M., Röhr, F., Wagner, S., Wulf, H. & Zoremba, M., Jan 2011, In: Anaesthesist. 60, 1, p. 39-48 10 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

2010

Intensivmedizinische Kompetenz Evidenz-basierte Medizin (EBM) in der Intensivmedizin

Translated title of the contribution: Intensive care medical competence - Evidence-based medicine (EBM) in intensive care medicineGerlach, H., 2010, In: Journal fur Anasthesie und Intensivbehandlung. 17, 1, p. 50-52 3 p.

Research output: Contribution to journal › Article › peer-review

Managing septic shock

Gerlach, H. & Toussaint, S., 24 May 2010, In: F1000 Medicine Reports. 2, 1, 40.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Pathophysiologie der Sepsis Rolle des Gefäßendothels

Translated title of the contribution: Pathophysiology of sepsis - Role of vascular endotheliumGerlach, H., 2010, In: Journal fur Anasthesie und Intensivbehandlung. 17, 1, p. 46-49 4 p.

Research output: Contribution to journal › Article › peer-review

Perioperative gene expression analysis for prediction of postoperative sepsis

Hinrichs, C., Kotsch, K., Buchwald, S., Habicher, M., Saak, N., Gerlach, H., Volk, H. D. & Keh, D., 1 Apr 2010, In: Clinical Chemistry. 56, 4, p. 613-622 10 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Klinik für Anästhesie, operative Intensivmedizin und Schmerztherapie

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