Detection of Chlamydophila pneumoniae in the bone marrow of two patients with unexplained chronic anaemia

C. Thomas Nebe; Marion Rother; Ingrid Brechtel; Victor Costina; Michael Neumaier; Hanswalter Zentgraf; Ulrich Böcker; Thomas F. Meyer; Agnes J. Szczepek

doi:10.1111/j.1600-0609.2004.00353.x

Detection of Chlamydophila pneumoniae in the bone marrow of two patients with unexplained chronic anaemia

C. Thomas Nebe, Marion Rother, Ingrid Brechtel, Victor Costina, Michael Neumaier, Hanswalter Zentgraf, Ulrich Böcker, Thomas F. Meyer, Agnes J. Szczepek

Klinik für Innere Medizin - Gastroenterologie, Diabetologie und Hepatologie

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Anaemia of chronic disease (ACD) is a common finding involving iron deficiency and signs of inflammation. Here, we report on two patients with ACD where a persistent infection with Chlamydophila (Chlamydia) pneumoniae (CP) was detected in bone marrow (BM) biopsies. Infection was suspected by routine cytology and confirmed by immunofluorescence, electron microscopy, polymerase chain reaction (PCR) including different primer sets and laboratories and sequencing of the PCR product. This is a first report of chlamydial presence in the BM of anaemic patients. The cases are presented because persistent chlamydial infection may contribute more frequently to chronic refractory anaemia than previously suspected.

Original language	English
Pages (from-to)	77-83
Number of pages	7
Journal	European Journal of Haematology
Volume	74
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0609.2004.00353.x
Publication status	Published - Jan 2005

Keywords

Anaemia
Bone marrow
Chlamydiales
Chlamydophila pneumoniae
Electron microscopy
Immunofluorescence
Infection
PCR
Sequencing

ASJC Scopus subject areas

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1600-0609.2004.00353.x

Cite this

@article{425535f89c584586a5ac4eb565d2758d,

title = "Detection of Chlamydophila pneumoniae in the bone marrow of two patients with unexplained chronic anaemia",

abstract = "Anaemia of chronic disease (ACD) is a common finding involving iron deficiency and signs of inflammation. Here, we report on two patients with ACD where a persistent infection with Chlamydophila (Chlamydia) pneumoniae (CP) was detected in bone marrow (BM) biopsies. Infection was suspected by routine cytology and confirmed by immunofluorescence, electron microscopy, polymerase chain reaction (PCR) including different primer sets and laboratories and sequencing of the PCR product. This is a first report of chlamydial presence in the BM of anaemic patients. The cases are presented because persistent chlamydial infection may contribute more frequently to chronic refractory anaemia than previously suspected.",

keywords = "Anaemia, Bone marrow, Chlamydiales, Chlamydophila pneumoniae, Electron microscopy, Immunofluorescence, Infection, PCR, Sequencing",

author = "Nebe, {C. Thomas} and Marion Rother and Ingrid Brechtel and Victor Costina and Michael Neumaier and Hanswalter Zentgraf and Ulrich B{\"o}cker and Meyer, {Thomas F.} and Szczepek, {Agnes J.}",

year = "2005",

month = jan,

doi = "10.1111/j.1600-0609.2004.00353.x",

language = "English",

volume = "74",

pages = "77--83",

journal = "European Journal of Haematology",

issn = "0902-4441",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Detection of Chlamydophila pneumoniae in the bone marrow of two patients with unexplained chronic anaemia

AU - Nebe, C. Thomas

AU - Rother, Marion

AU - Brechtel, Ingrid

AU - Costina, Victor

AU - Neumaier, Michael

AU - Zentgraf, Hanswalter

AU - Böcker, Ulrich

AU - Meyer, Thomas F.

AU - Szczepek, Agnes J.

PY - 2005/1

Y1 - 2005/1

N2 - Anaemia of chronic disease (ACD) is a common finding involving iron deficiency and signs of inflammation. Here, we report on two patients with ACD where a persistent infection with Chlamydophila (Chlamydia) pneumoniae (CP) was detected in bone marrow (BM) biopsies. Infection was suspected by routine cytology and confirmed by immunofluorescence, electron microscopy, polymerase chain reaction (PCR) including different primer sets and laboratories and sequencing of the PCR product. This is a first report of chlamydial presence in the BM of anaemic patients. The cases are presented because persistent chlamydial infection may contribute more frequently to chronic refractory anaemia than previously suspected.

AB - Anaemia of chronic disease (ACD) is a common finding involving iron deficiency and signs of inflammation. Here, we report on two patients with ACD where a persistent infection with Chlamydophila (Chlamydia) pneumoniae (CP) was detected in bone marrow (BM) biopsies. Infection was suspected by routine cytology and confirmed by immunofluorescence, electron microscopy, polymerase chain reaction (PCR) including different primer sets and laboratories and sequencing of the PCR product. This is a first report of chlamydial presence in the BM of anaemic patients. The cases are presented because persistent chlamydial infection may contribute more frequently to chronic refractory anaemia than previously suspected.

KW - Anaemia

KW - Bone marrow

KW - Chlamydiales

KW - Chlamydophila pneumoniae

KW - Electron microscopy

KW - Immunofluorescence

KW - Infection

KW - PCR

KW - Sequencing

UR - http://www.scopus.com/inward/record.url?scp=12444344944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12444344944&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0609.2004.00353.x

DO - 10.1111/j.1600-0609.2004.00353.x

M3 - Article

C2 - 15613113

AN - SCOPUS:12444344944

SN - 0902-4441

VL - 74

SP - 77

EP - 83

JO - European Journal of Haematology

JF - European Journal of Haematology

IS - 1

ER -

Detection of Chlamydophila pneumoniae in the bone marrow of two patients with unexplained chronic anaemia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this