TY - JOUR
T1 - Effect of renal denervation procedure on left ventricular mass, myocardial strain and diastolic function by CMR on a 12-month follow-up
AU - Tahir, Enver
AU - Koops, Andreas
AU - Warncke, Malte L.
AU - Starekova, Jitka
AU - Neumann, Johannes T.
AU - Waldeyer, Christoph
AU - Avanesov, Maxim
AU - Lund, Gunnar K.
AU - Fischer, Roland
AU - Adam, Gerhard
AU - Blankenberg, Stefan
AU - Wenzel, Ulrich O.
AU - Brunner, Fabian J.
N1 - Publisher Copyright:
© 2019, Japan Radiological Society.
PY - 2019/9/20
Y1 - 2019/9/20
N2 - Purpose: To investigate the effects of renal denervation (RDN) on left ventricular (LV) mass, myocardial strain and diastolic function in patients with treatment-resistant arterial hypertension by cardiac magnet resonance imaging on a 12-month follow-up. Materials and methods: Sixteen patients (38% female) were examined before and 12 months after RDN. LV morphology and strain were analyzed. Diastolic function was determined by early (EPFR) and atrial peak filling rates (APFR) derived from differential volume–time-curve analysis. Clinical visits included 24-h ambulant blood pressure monitoring (ABPM). Results: Twelve months after RDN LV mass decreased from 80 ± 21 g/m2 to 74 ± 20 g/m2 (P < 0.05). Global radial (35 ± 12% vs. 41 ± 10%, P < 0.05) and longitudinal strain improved (− 15 ± 4% vs. − 17 ± 3%, P < 0.05). Global circumferential strain (− 16 ± 5% vs. − 18 ± 4%, P = 0.12) remained unchanged. The parameter of diastolic LV function PFRR (EPFR/APFR) improved following RDN (0.9 ± 0.4 vs. 1.1 ± 0.5, P < 0.05). Individual changes of LV mass were associated with an increase of EPFR (r = − 0.54, P < 0.05) and a reduction of APFR by trend (r = 0.45, P = 0.08). Systolic ABPM showed a decrease by trend (152 mmHg vs. 148 mmHg, P = 0.08). Conclusions: After RDN we observed a reduction of LV mass, improvement of global strain and diastolic function.
AB - Purpose: To investigate the effects of renal denervation (RDN) on left ventricular (LV) mass, myocardial strain and diastolic function in patients with treatment-resistant arterial hypertension by cardiac magnet resonance imaging on a 12-month follow-up. Materials and methods: Sixteen patients (38% female) were examined before and 12 months after RDN. LV morphology and strain were analyzed. Diastolic function was determined by early (EPFR) and atrial peak filling rates (APFR) derived from differential volume–time-curve analysis. Clinical visits included 24-h ambulant blood pressure monitoring (ABPM). Results: Twelve months after RDN LV mass decreased from 80 ± 21 g/m2 to 74 ± 20 g/m2 (P < 0.05). Global radial (35 ± 12% vs. 41 ± 10%, P < 0.05) and longitudinal strain improved (− 15 ± 4% vs. − 17 ± 3%, P < 0.05). Global circumferential strain (− 16 ± 5% vs. − 18 ± 4%, P = 0.12) remained unchanged. The parameter of diastolic LV function PFRR (EPFR/APFR) improved following RDN (0.9 ± 0.4 vs. 1.1 ± 0.5, P < 0.05). Individual changes of LV mass were associated with an increase of EPFR (r = − 0.54, P < 0.05) and a reduction of APFR by trend (r = 0.45, P = 0.08). Systolic ABPM showed a decrease by trend (152 mmHg vs. 148 mmHg, P = 0.08). Conclusions: After RDN we observed a reduction of LV mass, improvement of global strain and diastolic function.
KW - Arterial hypertension
KW - Diastolic heart failure
KW - Left ventricular hypertrophy
KW - Myocardial strain
KW - Renal denervation
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U2 - 10.1007/s11604-019-00854-y
DO - 10.1007/s11604-019-00854-y
M3 - Article
C2 - 31301000
AN - SCOPUS:85068821691
SN - 1867-1071
VL - 37
SP - 642
EP - 650
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
IS - 9
ER -
