TY - JOUR
T1 - Mangelnde Medikamentenadhärenz bei Kindern und Jugendlichen mit ADHS
T2 - Ergebnisse einer multizentrischen prospektiven Beobachtungsstudie
AU - Mechler, Konstantin
AU - Banaschewski, Tobias
AU - Hellenschmidt, Tobias
AU - Correll, Christoph U.
AU - Theisen, Frank M.
AU - Kaess, Michael
AU - Kölch, Michael
AU - Libal, Gerhard
AU - Renner, Tobias J.
AU - Fegert, Jörg M.
AU - Karwautz, Andreas
AU - Plener, Paul L.
AU - Heuschmann, Peter
AU - Fekete, Stefanie
AU - Romanos, Marcel
AU - Egberts, Karin
AU - Häge, Alexander
N1 - Publisher Copyright:
© 2025 The Author(s) Distributed as a Hogrefe OpenMind article under the license.
PY - 2025/9/1
Y1 - 2025/9/1
N2 - Objective: Attention-deficit/hyperactivity disorder (ADHD) affects 6-10 % of children and adolescents worldwide. While psychopharmacological treatments effectively reduce symptoms, incomplete adherence is common, diminishing their effectiveness. This study investigated medication nonadherence and its predictors in children and adolescents with ADHD. Method: The TDM-VIGIL study, a multicenter prospective observational study in Germany, examined drug-related risks of ADHD medication in hyperkinetic disorders and nonadherence. Participants aged 6-18 years with ADHD (ICD-10/ DSM-IV) starting stimulants or nonstimulants were assessed for nonadherence using the Medication Assessment Questionnaire (MAQ) at multiple time points. Patients were classified as fully or not fully adherent, and logistic regression analysis was used to identify predictors. Results: Among 198 participants (mean age = 10.4 years), 66.1 %-75.4 % were fully adherent across time points. Higher age and lower intelligence were significantly associated with nonadherence, while sex, disease severity, adverse events, treatment setting (outpatient, day clinic, inpatient), medication class (stimulant, nonstimulant), and treatment strategy (mono- versus polypharmacy) were not. Conclusions: Medication nonadherence is common in youth with ADHD, with higher age and lower intelligence representing relevant risk factors. Clinicians should consistently monitor adherence and address individual barriers.
AB - Objective: Attention-deficit/hyperactivity disorder (ADHD) affects 6-10 % of children and adolescents worldwide. While psychopharmacological treatments effectively reduce symptoms, incomplete adherence is common, diminishing their effectiveness. This study investigated medication nonadherence and its predictors in children and adolescents with ADHD. Method: The TDM-VIGIL study, a multicenter prospective observational study in Germany, examined drug-related risks of ADHD medication in hyperkinetic disorders and nonadherence. Participants aged 6-18 years with ADHD (ICD-10/ DSM-IV) starting stimulants or nonstimulants were assessed for nonadherence using the Medication Assessment Questionnaire (MAQ) at multiple time points. Patients were classified as fully or not fully adherent, and logistic regression analysis was used to identify predictors. Results: Among 198 participants (mean age = 10.4 years), 66.1 %-75.4 % were fully adherent across time points. Higher age and lower intelligence were significantly associated with nonadherence, while sex, disease severity, adverse events, treatment setting (outpatient, day clinic, inpatient), medication class (stimulant, nonstimulant), and treatment strategy (mono- versus polypharmacy) were not. Conclusions: Medication nonadherence is common in youth with ADHD, with higher age and lower intelligence representing relevant risk factors. Clinicians should consistently monitor adherence and address individual barriers.
KW - ADHD
KW - adherence
KW - adolescents
KW - children
KW - compliance
KW - medication
KW - treatment
UR - https://www.scopus.com/pages/publications/105009229201
UR - https://www.scopus.com/inward/citedby.url?scp=105009229201&partnerID=8YFLogxK
U2 - 10.1024/1422-4917/a001034
DO - 10.1024/1422-4917/a001034
M3 - Article
AN - SCOPUS:105009229201
SN - 1422-4917
VL - 53
SP - 249
EP - 261
JO - Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
JF - Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
IS - 5
ER -